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AC-1 AC-2 AC-3 AC-4 AC-5 AC-6
AC-7
AC-8 AC-9 AC-10 AC-11 AC-12 AC-13 AC-14 AC-15 AC-16 AC-17 AC-18 AC-19 AC-20 AC-21 AC-22 AC-23 AC-24 AC-25 AC-26 AC-27 AC-28 AC-29
BAC-1 BAC-2 BAC-3 BAC-4 BAC-5

AC-7 - Few Nuclear Dots

Relevâncias Clínicas - Primeiro nível

The AC-7 pattern has low positive predictive value for any disease.
Onouchi, Muro & Tomita, 1999
Fujimoto, Kikuchi, Tamaki et al., 1997
Antigens primarily localized in the dots include p80-coilin and SMN complex; specific immunoassays for these autoantibodies are currently not commercially available.
Andrade, Chan, Raska et al., 1991
Satoh, Chan, Ross et al., 2011

Relevâncias Clínicas - Segundo nível

Anti-p80-coilin antibodies may rarely occur in SLE, (localized linear) SSc, and SjS.
Andrade, Chan, Raska et al., 1991
Fujimoto, Kikuchi, Tamaki et al., 1997
Onouchi, Muro & Tomita, 1999
Isolated (without anti-snRNPs) anti-SMN antibodies are reported in patients with AIM or SSc-AIM overlap syndrome.
Satoh, Chan, Ross et al., 2011
The specificity of antibodies to p80-coilin and the SMN complex can be confirmed by Western blot, solid phase immunoassays using recombinant proteins and immunoprecipitation.
Andrade, Chan, Raska et al., 1991
Satoh, Chan, Ross et al., 2011
Amlani, Hazlewood, Hamilton et al., 2018
Most reports describe autoantibodies directly binding to specific antigens (i.e. antigen-specific immunoassays) and do not actually show clear correlations with the AC-7 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available.
Damoiseaux, Andrade, Carballo et al., 2019