Relevância Clínica
- início
- Relevância Clínica
AC-13 - PCNA-like
Relevâncias Clínicas - Primeiro nível
The AC-13 pattern has formerly been considered highly specific for SLE, but this specificity is debated.
If SLE is clinically suspected, it is recommended to perform a follow-up test for anti-PCNA antibodies; the antigen is included in several routine ENA profiles.
Recent studies with antigen-specific immunoassays show clinical associations also with SSc, AIM, RA, HCV, and other conditions.
Relevâncias Clínicas - Segundo nível
A major challenge in deriving an association of the AC-13 pattern with antibodies to the classical 35 kDa PCNA (elongation factor of DNA polymerase delta auxiliary protein) is that “PCNA” is known to be a macromolecular complex where targets other than the ‘classical’ 35 kDa PCNA are present. In addition, a number of other apparently unrelated targets can also produce an AC-13-like pattern by HEp-2 IIFA.