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AC-1 AC-2 AC-3 AC-4 AC-5 AC-6 AC-7 AC-8 AC-9 AC-10 AC-11 AC-12 AC-13 AC-14 AC-15 AC-16 AC-17
AC-18
AC-19 AC-20 AC-21 AC-22 AC-23 AC-24 AC-25 AC-26 AC-27 AC-28 AC-29
BAC-1 BAC-2 BAC-3 BAC-4 BAC-5

AC-18 - Discrete Dots

Relevâncias Clínicas - Primeiro nível

Autoantibodies revealing the AC-18 pattern have been reported in distinct SARD and in a variety of other diseases; their prevalence in unselected or specified disease cohorts has not been thoroughly studied
Bhanji, Eystathioy, Chan et al., 2007
Antigens recognized include GW-body (Processing or P body) antigens (Ge- 1/Hedls, GW182, and Su/Ago2) and endosomal antigens (EEA1, CLIP-170, GRASP-1, and LBPA); specific immunoassays for these autoantibodies are currently not commercially available
Damoiseaux, Andrade, Carballo et al., 2019
Autoantibodies to GW-bodies and endosomes may yield slightly different HEp-2 IIFA patterns.
Bhanji, Eystathioy, Chan et al., 2007
Stinton, Eystathioy, Selak et al., 2004

Relevâncias Clínicas - Segundo nível

Autoantibodies to GW bodies. The most common clinical presentations in a single study with 55 positive sera were neurological symptoms (i.e. ataxia, motor and sensory neuropathy; 33%), SjS (31%), and the remainder had a variety of other diagnoses including SLE, RA, and PBC.
Bhanji, Eystathioy, Chan et al., 2007
Autoantibodies to GW bodies. Analysis by ALBIA and immunoprecipitation of recombinant proteins indicated that autoantibodies were directed against Ge-1/Hedls (58%), GW182 (40%), and Su/Ago2 (16%)
Bhanji, Eystathioy, Chan et al., 2007
Autoantibodies to endosomal components.Autoantibodies to EEA1 were seen in a variety of conditions, but ~40% of the patients had a neurological disease.
Stinton, Eystathioy, Selak et al., 2004
Autoantibodies to endosomal components. Autoantibodies to CLIP-170 were reported in 4 patients with different diseases including the prototype patient with SLE and AIM; the remaining 3 patients had limited cutaneous SSc, glioblastoma, and idiopathic pleural effusion.
Griffith, Ryan, Senecal et al., 2002
Autoantibodies to endosomal components. Autoantibodies to both LBPA and GRASP-1 have not been studied thoroughly in unselected or specified disease cohorts; anti-GRASP-1 autoantibodies were detected in 17% of PBC sera.
Stinton, Selak & Fritzler, 2005
Stinton, Swain, Myers et al. 2011
Autoantibodies to endosomal components. Autoantibodies to both LBPA and GRASP-1 have not been studied thoroughly in unselected or specified disease cohorts; anti-GRASP-1 autoantibodies were detected in 17% of PBC sera.
Most reports describing autoantibodies directly binding to specific endosomal antigens do not show correlations with the AC-18 pattern as such; specific immunoassays for the autoantibodies reacting with antigens of GW bodies or endosomes are currently not commercially available.
Damoiseaux, Andrade, Carballo et al., 2019