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AC-1 AC-2 AC-3 AC-4 AC-5 AC-6 AC-7 AC-8 AC-9 AC-10 AC-11 AC-12 AC-13 AC-14
AC-15
AC-16 AC-17 AC-18 AC-19 AC-20 AC-21 AC-22 AC-23 AC-24 AC-25 AC-26 AC-27 AC-28 AC-29
BAC-1 BAC-2 BAC-3 BAC-4 BAC-5

AC-15 - Fibrillar Linear

Relevâncias Clínicas - Primeiro nível

Found in patients with AIH type 1, chronic HCV infection, and celiac disease (IgA isotype); rare in SARD.
Conrad, Schössler & Hiepe, 2017
If AIH type 1 is clinically suspected, it is recommended to confirm reactivity with smooth muscle antibodies (IgG isotype), typically detected by IIFA on rodent tissue (liver, stomach, kidney); anti-smooth muscle antibodies are included in the international criteria for AIH type 1.
Conrad, Schössler & Hiepe, 2017
Liberal, Grant, Longhi et al., 2014
F-actin is the main target antigen of anti-smooth muscle antibodies in AIH type 1; autoantibodies to F-actin are of more clinical importance than antibodies to G-actin.
Lidman, Biberfeld, Fagraeus et al., 1976
Fusconi, Cassani, Zauli et al., 1990
Chretien-Leprince, Ballot, Andre et al., 2005
Although anti-F-actin immunoassays are commercially available, technical issues relating to the sensitivity of these immunoassays should be taken into consideration.
Damoiseaux, Andrade, Carballo et al., 2019
High prevalence of IgA and/or IgG type anti-actin antibody has been reported in celiac disease.
Pedreira, Sugai, Moreno et al., 2005
von Muhlen, Chan, Peebles et al., 1995
Monoclonal antibodies to non-muscle myosin have been reported in chronic lymphocytic leukemia.
Chu, Catera, Hatzi et al., 2008

Relevâncias Clínicas - Segundo nível

Specific immunoassays for non-muscle myosin are currently not commercially available.
Damoiseaux, Andrade, Carballo et al., 2019