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AC-1 AC-2 AC-3 AC-4 AC-5 AC-6 AC-7 AC-8 AC-9 AC-10 AC-11 AC-12 AC-13 AC-14 AC-15 AC-16 AC-17 AC-18 AC-19 AC-20 AC-21 AC-22 AC-23 AC-24 AC-25 AC-26
AC-27
AC-28 AC-29
BAC-1 BAC-2 BAC-3 BAC-4 BAC-5

AC-27 - Intercellular Bridge

Relevâncias Clínicas - Primeiro nível

The AC-27 pattern has low positive predictive value for any disease
Rattner, Mack & Fritzler, 1998
Found very infrequently in a routine serology diagnostic setting
Vermeersch et al., 2013
"Antigens recognized include, among other, CENP-E, CENP-F, TD60, MSA36, KIF-14, MKLP-1, MPP1/ KIF20B, and INCENP; specific immunoassays for these autoantibodies are currently not commercially available "
Rattner, Mack & Fritzler, 1998
Humbel RLConrad, 2013
Rodríguez-Bayona et al., 2007

Relevâncias Clínicas - Segundo nível

Incidentally described in patients with SSc, Raynaud’s phenomenon, and malignancy
Fritzler et al., 1987
Tausche et al., 2005
Vermeersch & Bossuyt, 2013
Autoantibodies to CENP-E, CENP-F, TD60, MSA36, KIF-14, and MKLP-1 have been described in patients with SSc (limited and diffuse), SLE, and malignancies
Rattner, Mack & Fritzler, 1998
Autoantibodies to CENP-E, CENP-F, TD60, MSA36, KIF-14, and MKLP-1 have been described in patients with SSc (limited and diffuse), SLE, and malignancies
Humbel, 2013
Autoantibodies to INCENP have been described in a single patient with Graham-Little-Piccardi-Lasseur Syndrome
Rodriguez-Bayona et al., 2007
Autoantibodies to MPP1 /KIF20B (M-phase phosphoprotein 1) have been described in patients with idiopathic ataxia, other neurological syndromes and paroxysmal nocturnal haemoglobinuria
Fritzler et al., 2000
Alahmad et al., 2010
Most reports describe autoantibodies directly binding to specific antigens (i.e., antigen-specific immunossays) and do not actually show correlations with the AC-27 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available.