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AC-1 AC-2 AC-3 AC-4 AC-5 AC-6 AC-7 AC-8 AC-9 AC-10 AC-11
AC-12
AC-13 AC-14 AC-15 AC-16 AC-17 AC-18 AC-19 AC-20 AC-21 AC-22 AC-23 AC-24 AC-25 AC-26 AC-27 AC-28 AC-29
BAC-1 BAC-2 BAC-3 BAC-4 BAC-5

AC-12 - Punctate Nuclear Envelope

Relevâncias Clínicas - Primeiro nível

Found in patients with PBC, as well as patients with other autoimmune liver diseases and SARD.
Miyachi, Hankins, Matsushima et al., 2003
If PBC is clinically suspected, it is recommended to perform a follow-up test for anti-gp210 antibodies; the antigen is included in disease specific immunoassays (ie, extended liver profile).
Courvalin, Lassoued, Bartnik et al., 1990
Nickowitz & Worman, 1993
Bandin, Courvalin, Poupon et al., 1996
Other antigens recognized include p62 nucleoporin, LBR, and Tpr; specific immunoassays for these autoantibodies are currently not commercially available.
Wesierska-Gadek, Klima, Komina et al., 2007
Kraemer & Tony, 2010
Courvalin, Lassoued, Worman et al., 1990
Ou, Enarson, Rattner et al., 2004

Relevâncias Clínicas - Segundo nível

Anti-p62 nucleoporin antibodies have been described in PBC and SLE.
Wesierska-Gadek, Klima, Komina et al., 2007
Kraemer & Tony, 2010
Anti-LBR antibodies have been described in PBC.
Courvalin, Lassoued, Worman et al., 1990
Anti-Tpr antibodies have been described in PBC, autoimmune liver disease, SLE, SSc and SjS.
Ou, Enarson, Rattner et al., 2004
Most reports describe autoantibodies directly binding to specific antigens (i.e., antigen-specific immunoassays) and do not actually show clear correlations with the AC-12 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available.
Damoiseaux, Andrade, Carballo et al., 2019