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AC-1 AC-2 AC-3 AC-4 AC-5 AC-6 AC-7 AC-8 AC-9 AC-10 AC-11 AC-12 AC-13 AC-14 AC-15 AC-16
AC-17
AC-18 AC-19 AC-20 AC-21 AC-22 AC-23 AC-24 AC-25 AC-26 AC-27 AC-28 AC-29
BAC-1 BAC-2 BAC-3 BAC-4 BAC-5

AC-17 - Fibrillar Segmental

Relevâncias Clínicas - Primeiro nível

Found very infrequently in a routine serology diagnostic setting. Antigens recognized include ?-Actinin and Vinculin; specific immunoassays for these autoantibodies are currently not commercially available
Damoiseaux, Andrade, Carballo et al., 2019

Relevâncias Clínicas - Segundo nível

In SLE and lupus nephritis cross-reactive anti-?-actinin and anti-dsDNA autoantibodies have been reported as pathogenic
Zhao, Weinstein, Tuzova et al., 2005
Reported as part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis; also reported as a biomarker to differentiate patients with lupus nephritis from those without renal involvement
Seret, Canas, Pougnet-Di Costanzo et al., 2015
Zhang, Pan, Zhao et al., 2010
"Reported with relatively high prevalence (~40%) in patients with AIH type 1 and associated with more severe disease, clinical and histological disease activity, predictor of therapeutic response, and double positivity with anti-ssDNA antibodies Autoantibodies to vinculin: "
Gueguen, Dalekos, Nousbaum et al., 2006
Renaudineau, Dalekos, Gueguen et al., 2008
Zachou, Oikonomou, Renaudineau et al., 2008
Reported in 2 of 31 patients with chronic inflammatory demyelinating neuropathy
Beppu, Sawai, Satoh et al ., 2015
Most reports describe autoantibodies directly binding to specific antigens (i.e. antigen-specific immunoassays) and none actually shows correlations with the AC-17 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available.
Damoiseaux, Andrade, Carballo et al., 2019