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AC-2 - Dense fine speckled
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Commonly found as high titer HEp-2 IIFA-positive in apparently healthy individuals or in patients who do not have a systemic autoimmune rheumatic disease (SARD).
                                
                            The negative association with SARD is only valid if the autoreactivity is confirmed as being directed to DFS70 (also known as LEDGF/p75) and if no other common ENA is recognized.
                                
                            Both in apparently healthy individuals as well as patients who do not have a SARD the AC-2 pattern may be caused by autoantibodies to other antigens than DFS70.
                                
                            Confirmatory assays for anti-DFS70 antibodies may be available only in specialty clinical laboratories.
                                
                             
                     
                    