entre
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cadastre-se

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AC-1 AC-2 AC-3 AC-4 AC-5 AC-6 AC-7 AC-8 AC-9 AC-10 AC-11 AC-12 AC-13 AC-14 AC-15 AC-16 AC-17 AC-18 AC-19 AC-20
AC-21
AC-22 AC-23 AC-24 AC-25 AC-26 AC-27 AC-28 AC-29
BAC-1 BAC-2 BAC-3 BAC-4 BAC-5

AC-21 - Reticular/Ama

Relevâncias Clínicas - Primeiro nível

Commonly found in PBC, but also detected in SSc, including PBC-SSc overlap syndrome and PBC-SjS overlap syndrome
European Association for the Study of the Liver, 2017
Shuai et al., 2017
Skare et al., 2011
Zheng et al., 2017
Nardi et al., 2006
"If PBC is clinically suspected it is recommended to perform a follow-up test for AMA, historically detected by IIFA on rodent tissue (liver, stomach, kidney); these autoantibodies are primarily directed to the PDH complex, and in particular the E2-subunit (PDH-E2); the antigen is included in disease specific immunoassays (i.e., liver profile*) as well as in some routine ENA profiles "
European Association for the Study of the Liver, 2017
Shuai et al., 2017
Additional antigens recognized include the E1? and E1? subunits of PDH, the E3-binding protein of PDH, and the 2-OGDC; these antigens are only included in extended disease specific immunoassays (i.e., extended liver profile*)
European Association for the Study of the Liver, 2017
Shuai et al., 2017