CBA - Consenso Brasileiro de Autoanticorpos

Padrões

início
Padrões
BAC-4 - NUCLEAR COARSE RETICULATE SPECKLED

AC-1 AC-2 AC-3 AC-4 AC-5 AC-6 AC-7 AC-8 AC-9 AC-10 AC-11 AC-12 AC-13 AC-14 AC-15 AC-16 AC-17 AC-18 AC-19 AC-20 AC-21 AC-22 AC-23 AC-24 AC-25 AC-26 AC-27 AC-28 AC-29

BAC-1 BAC-2 BAC-3

BAC-4

BAC-5

BAC-4 - NUCLEAR COARSE RETICULATE SPECKLED

Descrição

Irregularly shaped and sparse nuclear domains (1-3µm) interconnected by a faint thread network.

Associação Antigênica

Antigenic targets include heterogeneous nuclear RNA (hnRNA) and nuclear matrix proteins.

Doenças Associadas

Although found in SARD, this pattern is most frequently observed in a vast array of non-autoimmune diseases.

Relevâncias Clínicas - Primeiro nível

Per se, this pattern represents weak evidence of systemic autoimmunity; however, SARD should be investigated according to the clinical presentation of the individual patient.

Cruvinel, Andrade, von Mühlen et al., 2019

Referências

Cruvinel Wilson de Melo, Andrade Luis Eduardo Coelho, von Mühlen Carlos Alberto, et al . V Brazilian consensus guidelines for detection of anti-cell autoantibodies on hep-2 cells. Adv. rheumatol. 2019; 59: 28.