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cadastre-se

Padrões

AC-1 AC-2 AC-3 AC-4 AC-5 AC-6 AC-7 AC-8 AC-9 AC-10 AC-11 AC-12 AC-13 AC-14 AC-15 AC-16
AC-17
AC-18 AC-19 AC-20 AC-21 AC-22 AC-23 AC-24 AC-25 AC-26 AC-27 AC-28 AC-29
BAC-1 BAC-2 BAC-3 BAC-4 BAC-5

AC-17 - Fibrillar Segmental

Descrição

Enhanced decoration of short segments, periodic dense bodies, along the stress fibers. e.g. anti-alpha-actinin, anti-vinculin.

Associação Antigênica

alpha-actinin, vinculin

Doenças Associadas

myasthenia gravis, Crohn`s disease, ulcerative colitis

Relevâncias Clínicas - Primeiro nível

Found very infrequently in a routine serology diagnostic setting. Antigens recognized include ?-Actinin and Vinculin; specific immunoassays for these autoantibodies are currently not commercially available
Damoiseaux, Andrade, Carballo et al., 2019

Relevâncias Clínicas - Segundo nível

In SLE and lupus nephritis cross-reactive anti-?-actinin and anti-dsDNA autoantibodies have been reported as pathogenic
Zhao, Weinstein, Tuzova et al., 2005
Reported as part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis; also reported as a biomarker to differentiate patients with lupus nephritis from those without renal involvement
Seret, Canas, Pougnet-Di Costanzo et al., 2015
Zhang, Pan, Zhao et al., 2010
"Reported with relatively high prevalence (~40%) in patients with AIH type 1 and associated with more severe disease, clinical and histological disease activity, predictor of therapeutic response, and double positivity with anti-ssDNA antibodies Autoantibodies to vinculin: "
Gueguen, Dalekos, Nousbaum et al., 2006
Renaudineau, Dalekos, Gueguen et al., 2008
Zachou, Oikonomou, Renaudineau et al., 2008
Reported in 2 of 31 patients with chronic inflammatory demyelinating neuropathy
Beppu, Sawai, Satoh et al ., 2015
Most reports describe autoantibodies directly binding to specific antigens (i.e. antigen-specific immunoassays) and none actually shows correlations with the AC-17 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available.
Damoiseaux, Andrade, Carballo et al., 2019

Referências

Beppu M, Sawai S, Satoh M, et al. Autoantibodies against vinculin in patients with chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol 2015;287:9-15. Gueguen P, Dalekos G, Nousbaum JB, et al. Double reactivity against actin and alpha-actinin defines a severe form of autoimmune hepatitis type 1. J Clin Immunol 2006;26:495-505. Renaudineau Y, Dalekos GN, Gueguen P, et al. Anti-alpha-actinin antibodies cross-react with anti-ssDNA antibodies in active autoimmune hepatitis. Clin Rev Allergy Immunol 2008);34:321-5. Seret G, Canas F, Pougnet-Di Costanzo L, et al. Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis. J Autoimmun 2015;61:54-61. Zachou K, Oikonomou K, Renaudineau Y, et al. Anti-alpha actinin antibodies as new predictors of response to treatment in autoimmune hepatitis type 1. Aliment Pharmacol Ther 2012;35:116-25. Zhang WH, Pan HF, Zhao XF, et al. Anti-alpha-actinin antibodies in relation to new-onset systemic lupus erythematosus and lupus nephritis. Mol Biol Rep 2010;37:1341-5. Zhao Z, Weinstein E, Tuzova M, et al. Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential. Arthritis Rheum 2005;52:522-30.