entre
ou
cadastre-se

Padrões

AC-1 AC-2 AC-3 AC-4 AC-5 AC-6 AC-7 AC-8 AC-9 AC-10
AC-11
AC-12 AC-13 AC-14 AC-15 AC-16 AC-17 AC-18 AC-19 AC-20 AC-21 AC-22 AC-23 AC-24 AC-25 AC-26 AC-27 AC-28 AC-29
BAC-1 BAC-2 BAC-3 BAC-4 BAC-5

AC-11 - Smooth Nuclear Envelope

Descrição

Homogeneous staining of the nucleus with greater intensity at its outer rim and no staining at the metaphase and anaphase chromatin plates. There is a peculiar accentuation of the fluorescence at the points where adjacent cells touch each other. e.g. anti-lamin B.

Associação Antigênica

lamins A,B,C, or lamin-associated proteins

Doenças Associadas

SLE, SjS, seronegative arthritis

Relevâncias Clínicas - Primeiro nível

The AC-11 pattern is infrequently found in routine autoantibody testing and has been described in autoimmune-cytopenias, autoimmune liver diseases, linear scleroderma, APS, and SARD; current information on clinical associations is based mainly on case reports and small cohorts.
Coppo, Clauvel, Bengoufa et al., 1987
Konstantinov, Foisner, Byrd, et al., 1995
Reeves, Chaudhary, Salerno et al., 1987
Antigens recognized include lamins (A, B, C) and LAP-2; specific immunoassays for these autoantibodies are currently not commercially available.
Coppo, Clauvel, Bengoufa et al., 1987
Konstantinov, Foisner, Byrd, et al., 1995
Reeves, Chaudhary, Salerno et al., 1987

Referências

Coppo P, Clauvel JP, Bengoufa D, et al. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol 2004;77:241–9. Konstantinov K, Foisner R, Byrd D, et al. Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol 1995;74:89–99. Reeves WH, Chaudhary N, Salerno A, et al. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med 1987;165:750–62.