Staining of the intercellular bridge that connects daughter cells by the end of cell division, but before cell separation.
rare in SSc, Raynaud`s phenomenon, malignancy
Relevância Clínica (Primeiro Nível)
The AC-27 pattern has low positive predictive value for any disease
Found very infrequently in a routine serology diagnostic setting
Antigens recognized include, among other, CENP-E, CENP-F, TD60, MSA36, KIF-14, MKLP-1, MPP1/ KIF20B, and INCENP; specific immunoassays for these autoantibodies are currently not commercially available
Relevância Clínica (Segundo Nível)
Incidentally described in patients with SSc, Raynaud’s phenomenon, and malignancy
Autoantibodies to CENP-E, CENP-F, TD60, MSA36, KIF-14, and MKLP-1 have been described in patients with SSc (limited and diffuse), SLE, and malignancies
Autoantibodies to INCENP have been described in a single patient with Graham-Little-Piccardi-Lasseur Syndrome
Autoantibodies to MPP1 /KIF20B (M-phase phosphoprotein 1) have been described in patients with idiopathic ataxia, other neurological syndromes and paroxysmal nocturnal haemoglobinuria
Most reports describe autoantibodies directly binding to specific antigens (i.e., antigen-specific immunossays) and do not actually show correlations with the AC-27 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available.
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