AC-28 - Mitotic Chromosomal
Descrição
Punctate coloration of chromosomes in pro- and metaphase with no staining of interphase cells.
Associação Antigênica
modified histone H3, MCA-1
Doença Associada
rare in discoid lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica
Relevância Clínica (Primeiro Nível)
The AC-28 pattern has low positive predictive value for any disease
Found very infrequently in a routine serology diagnostic setting
Antigens recognized include DCA, MCA1, and MCA5; specific immunoassays for these autoantibodies are currently not commercially available
Relevância Clínica (Segundo Nível)
Autoantibodies to DCA have been described in patients with SLE
Autoantibodies to MCA1 have been described in patients with carcinoma
Autoantibodies to MCA5 have been described in patients with discoid lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica
Specific immunoassays for these autoantibodies are currently not commercially available.
Referências
Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172–82.
Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329–38.
Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71–80.