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- Citoplasmáticos

Associação Antigênica
Doença Associada
Relevância Clínica (Primeiro Nível)
Commonly found in patients with limited cutaneous SSc, and as such included in the classification criteria for SSc.
In combination with Raynaud phenomenon, the AC-3 pattern is prognostic for onset of limited cutaneous SSc.
Strongly associated with antibodies to CENP-B; especially in case of low titers, confirmation by an antigen-specific immunoassay is recommended to support the association with limited cutaneous SSc; the CENP-B antigen is included in many routine ENA profiles.
The AC-3 pattern is also apparent in a subset of patients with PBC; these patients often have both SSc as well as PBC.
Relevância Clínica (Segundo Nível)
The AC-3 pattern is found in a subset of patients with SjS; these patients show mild SSc features, but a full-blown SjS clinical feature, more severe exocrine glandular dysfunction, and high risk of lymphoma.
The AC-3 pattern is also apparent in a subset of patients with SLE; these patients often have some degree of overlap with SSc.
Most sera with the AC-3 pattern react with CENP-A and CENP-B; antibodies to CENP-A can be detected by ELISA or disease specific immunoassays (i.e., SSc profile).
In rare cases AC-3 positive, but CENP-B negative sera of SSc patients may be strongly positive for anti-CENP-A antibodies.
Availability of assays for CENP-A, i.e., ELISA or SSc profile, may be limited to specialty clinical laboratories; specific immunoassays for anti-CENP-C antibodies are currently not commercially available.